ltcs-calculator: largest thermodynamically consistent sets of elementary flux modes
Given a set of elementary flux modes (EFMs), ltcs-calculator calcualtes the largest thermodynamically consistent sets (LTCSs) of EFMs. An LTCS contains the maximum number of EFMs that can be combined to form a thermodynamically feasible flux distribution.
Implementation
ltcs-calculator is a collection of (command-line) software tools written in C and perl.
Download
ltcs-calculator is freely available under either the 2-Clause BSD License at GitHub
The flux cone and its segmentation into LTCSs (i.e., subcones spanned by EFMs of an LTCS).
References
Matthias P. Gerstl, Christian Jungreuthmayer, Stefan Müller, and Jürgen Zanghellini. Which sets of elementary flux modes form thermodynamically feasible flux distributions? The FEBS Journal 283:1782 (2016). DOI:10.1111/febs.1370