Vitamin E – Novel Derivatives and Applications

  • Synthesis of novel phenolic antioxidants and studies of their antioxidative action
  • Design of multi-functional stabilizers for polymers
  • Synthesis of novel vitamin E (tocopherol) derivatives with medical applications
  • Design of novel stabilizers based on vitamin E for application as antioxidants in plastics, food packaging and polymers for medical use
  • Experimental, theoretical and computational studies of antioxidative action EPR and spin trapping studies
  • Clarification of reaction mechanisms and metabolic pathways of vitamin E derivatives
  • Ubiquinol / ubiquinon derivatives and related compounds

Key publications:

  1. Rosenau, T.; Potthast, A.; Ebner, G.; Hofinger, A.; Kosma, P. Org. Lett. 2002, 4(8), 1257-1258. Novel Tocopheryl Compounds XII. On a novel chromanone - naphthalenetrione rearrangement related to vitamin E chemistry.
  2. Rosenau, T.; Adelwöhrer, C.; Hofinger, A.; Mereiter, K.; Kosma, P. Eur. J. Org. Chem. 2004, 6, 1323-1329. Novel tocopheryl compounds XVII. 3-Tocopherylisoxazolines by [2+3]-cycloaddition.
  3. Adelwöhrer, C.; Rosenau, T.; Kosma, P. Tetrahedron 2003, 59(41), 8177-8182. Novel Tocopheryl Compounds XVI. Nitration of a-Tocopheryl Acetate – a Mechanistic Study.
  4. Rosenau, T.; Adelwöhrer, C.; Hofinger, A.; Mereiter, K.; Kosma, P. Eur. J. Org. Chem. 2004, 6, 1323-1329. Novel Tocopheryl Compounds XVII. 3-Tocopheryl-isoxazolines by [2+3]-Cycloaddition.
  5. Staniek, K.; Rosenau, T.; Gregor, W.; Nohl, H.; Gille. L. Biochem. Pharmacol. 2005, 70, 1361–1370. The protection of bioenergetic functions in mitochondria by new synthetic chromanols.
  6. Adelwöhrer, C.; Rosenau, T.; Kloser, E.; Mereiter, K.; Netscher, T. Eur. J. Org. Chem. 2006, 9, 2081-2086. Novel Tocopheryl Compounds XXIII. Synthesis of 5a-a-tocopheryl azide and its reaction to 1-(5a-a-tocopheryl)-1,2,3-triazols by [2+3]-cycloaddition.
  7. Patel, A.; Liebner, F.; Netscher, T.; Mereiter, K.; Rosenau, T. J. Org. Chem. 2007, 72(17), 6504-6512. Nitration of non-alpha tocopherols – products and mechanistic considerations.
  8. Gille, L.; Stamberg, W.; Jäger, W.; Reznicek, G.; Netscher, T.; Rosenau, T. Chem. Res. Toxicol. 2007, 20(4), 591-599. A new ubiquinone metabolite and its activity at the mitochondrial bc1 complex.